The Noise Reduction and Sharpening sliders might be the obvious go-to tools for optimizing high-ISO images, but these can easily leave you with soft, wishy-washy detail or exaggerated noise as you try to play one off against the other. In fact, there are better ways to get your high-ISO images looking smoother and sharper.
Texture slider (Lightroom)
A relatively new adjustment in Adobe Lightroom which is somewhere between Sharpening and Clarity. It adds definition and the appearance of crisper detail to objects, though it can increase the appearance of noise, too.